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Medical Research: Parkinson's Disease Breakthrough Could 'Stop The Condition In Its Tracks' - by Thomas Tamblyn

New research by scientists at the University of Leicester has provided a breakthrough in understanding the origins of Parkinson’s disease which could eventually lead to a cure.

The scientists have discovered that the area of a cell responsible for correctly assembling key proteins could play much more significant role in the disease than previously thought.

It had originally been though that Parkinson’s occurs when the power source for cells malfunctions.

It now turns out that the majority of the problem lies in another part of the cell called the endoplasmic reticulum (ER).

The ER’s job is to fold vital proteins that are used by the cell, if it malfunctions the cell will halt production of these proteins and ultimately die.

Read more: Parkinson's Disease Breakthrough Could 'Stop The Condition In Its Tracks'

Brexit: More Than 2 Million Britons Are now Demanding A Second EU Referendum - by Lee Moran

Calls for the United Kingdom to hold a second referendum on its membership of the European Union are growing.

A petition demanding a rerun of Thursday’s vote which resulted in the British exit, dubbed a “Brexit,” after the “leave” campaign won 51.9 percent to Remain’s 48.1 percent, had garnered more than 2 million signatures by midday on Saturday

Readv more: More Than 2 Million Britons Are Demanding A Second EU Referendum

USA: Hillary Clinton Camp Says Trump’s ‘Brexit’ Remarks Show He’s Unfit for White House - by P. Nicholas and L. Meckler

Hillary Clinton’s campaign moved swiftly to cast Republican opponent Donald Trump’s reaction to the “Brexit” vote as evidence as he is unfit to be president.

In a conference call with reporters Friday, Mrs. Clinton’s top aides sought to draw a contrast between what they described as Mrs. Clinton’s steady leadership during such global crises and Mr. Trump’s fixation on his own business interests.

They cited the news conference Mr. Trump gave at his newly-renovated golf course in Scotland on Friday. Should the British pound fall in the wake of the Brexit vote, that would be a boon to his golf business in Turnberry, Scotland, Mr. Trump told reporters, drawing more business. (It was down to its weakest level in 30 years on Friday afternoon.)

Jake Sullivan, a senior campaign adviser to Mrs. Clinton, said that Mr. Trump is “rooting for economic turmoil” touched off by Britain’s vote to leave the European Union.

“He actually put his golf business ahead of the interests of working families

Read more: Hillary Clinton Camp Says Trump’s ‘Brexit’ Remarks Show He’s Unfit for White House - Washington Wire - WSJ

EU Commission: Britain's EU commissioner, finance chief Hill, resigns

The British member of the EU executive, Financial Services Commissioner Jonathan Hill, resigned on Saturday after having campaigned against Britain leaving the European Union.

Following the referendum vote for Brexit on Thursday, few expected a Briton to retain oversight of the EU banking and finance market that will be a key battleground in negotiations between London and Brussels on dissolving British membership.

European Commission President Jean-Claude Juncker said he was handing the portfolio to Valdis Dombrovskis, who will take it into his brief as vice president for the euro from July 16.

An EU official said the move made it clear that plans for an EU capital markets union would now focus on the euro zone after Hill had worked to ensure new EU rules would not disadvantage London's huge finance industry based outside the currency area.

"It's clear there will be a less clear division between the capital markets union and the euro zone," the official said.

London-based banks and other financial firms are concerned about access to the EU once Britain leaves the single market.

Hill said in a statement a day after British voters backed Brexit in a referendum called by Prime Minister David Cameron: "I don't believe it is right that I should carry on as the British commissioner as though nothing had happened."

Dombrovskis, who as prime minister took Latvia into the euro, and whose current role already oversees Hill's portfolio, said his priority was to maintain financial stability in markets.

Cameron, who will be replaced once his Conservative party elects a new leader, will leave it to his successor to discuss what to do with Britain's seat on the Commission, a British spokesperson said. It retains the right to a seat, along with the 27 other EU states, until it finally leaves the Union.

Read more: Britain's EU commissioner, finance chief Hill, resigns | Reuters

Donald Trump's Presidential Campaign Has A Lot In Common With Brexit And Other Nationalist Movements - by Scot Detrow

When Donald Trump arrived in Scotland Friday morning, hours after the United Kingdom voted to leave the European Union, the presumptive Republican presidential nominee was quick to draw parallels between the U.K.'s political earthquake, and his own campaign for president.

"People want to take their country back," Trump said, "They want to have independence, in a sense. And you see it in Europe, all over Europe."

And while Scotland itself voted overwhelmingly to remain in the European Union, Trump is right. Right-wing nationalist movements, fueled by anger toward political elites and mistrust of immigration — and primarily backed by white voters — are gaining more and more momentum on the continent.

"This is not a unique phenomenon to the United States, and 2016 is not a short moment that will pass," says Yascha Mounk, who teaches political theory at Harvard University and has studied the rise of nationalist movements. "This is a real populist turn that has been happening for the last 15 or 20 years."

In recent decades, nationalist movements have shifted from vocal minorities to powerful parties that gained control of governments in places like Hungary, have lost national elections by the slimmest of margins in countries like Austria, and, this week, forced the United Kingdom out of the European Union.

Read more: Donald Trump's Presidential Campaign Has A Lot In Common With Brexit And Other Nationalist Movements : NPR

Brexit: Second Referendum Petition Gains More than 1 Million Signatures - by Conor Gaffey

A backlash has begun among British supporters of the U.K. remaining in the European Union, with a petition calling for a second referendum more than one million signatures.

The petition, created on Friday, has already gained far more than the 100,000 signatures required for it to be considered by the U.K. parliament for a debate and has caused the parliament website to crash several times due to high demand.

Read more: Brexit: Second Referendum Petition Gains More than 1 Million Signatures


Britain: EU bosses order Britain to "Pack your bags and get out now"

As the Britanic Sails Away
EU bosses ordered Britain: “Pack your bags and get out now.”

The strongly worded message in the wake of Thursday’s Leave vote was designed to stop a domino effect of EU exits and calm the ­frenzied money markets.

Far-right groups in France and Holland seized on the result to demand their own exit referendums.

In Brussels, EU chiefs said they “regret but respect” our decision and that the UK must remain “a close partner”.

But in a clear sign of the battles ahead, a statement from bosses including European Council boss Donald Tusk and European Commission president Jean Claude Juncker called on the UK to start Brexit ­immediately. It said: “We now expect the government to give effect to this decision of the British people as soon as possible, however painful that process may be.

“Any delay would unnecessarily prolong uncertainty.”

There are around 1.2 million British born people living in EU countries without visas, according to figures provided by the UN. Around 800,000 are workers and their dependants.

The European Commission, presently employs 1,000 U.K. nationals as civil servants across its various departments.

Also for the soon to become redundant former British EU citizens Brexit now means an uncertain future of either getting visas,work permits, going home, or worse case scenario, becoming a refugee themselves requesting asylum in the EU? 


Sctland seeks independence: Nicola Sturgeon: second Scottish independence poll highly likely - by Severin Carrell Libby Brooksand

Scotland is on the brink of staging a fresh referendum on independence after Nicola Sturgeon requested talks with the EU on separate membership after the UK’s vote to leave.

The first minister said she believed a second referendum on independence was highly likely after Scotland voted overwhelmingly to remain within the EU, but was unable to prevent the leave campaign winning by 52% to 48% across the UK as a whole.

Sturgeon said that was a “democratic outrage” and constituted the clear, material change in Scotland’s circumstances referred to in the Scottish National party’s carefully worded manifesto commitment in May to hold a second independence vote if needed.

“It is a significant material change in circumstances. It’s a statement of the obvious that the option of a second independence referendum must be on the table, and it is on the table,” she said.

Sturgeon announced that she was instructing Scottish government officials to draft fresh referendum legislation for Holyrood, only two years after her party lost the first independence vote in 2014, to ensure it could be held quickly if enough Scottish voters backed it.

UK government sources said David Cameron, who quit as prime minister after the referendum defeat, was anxious that his successor make sure the Scottish, Welsh and Northern Ireland government were closely involved in the UK’s Brexit negotiations to avoid increasing Scottish grievances and fuelling the case for independence.

Sturgeon’s cabinet will meet in emergency session on Saturday morning at her official residence Bute House, and is expected to agree plans to put forward referendum legislation in September’s programme for government.

Read more: Nicola Sturgeon: second Scottish independence poll highly likely | Politics | The Guardian

Brexit: A pyrrhic victory? Boris Johnson wakes up to the costs of Brexit - by Gaby Hinsliff

Party is over Britain: you are on your own
“If we are victorious in one more battle … we shall be utterly ruined.”

Like the good intellectual that he’s vigorously pretended not to be of late, Boris Johnson will probably know that line. It’s from the Greek historian Plutarch’s account of the battle that gave us the phrase “pyrrhic victory”, the kind of victory won at such cost that you almost wish you’d lost.

In theory, Johnson woke up on Friday morning having won the war. After David Cameron’s announcement that he would step down come October, Johnson is now the heir presumptive – albeit at this stage very presumptive – to the Tory leadership, perhaps only four months away from running the country.

He has everything he ever wanted. It’s just that somehow, as he fought his way through booing crowds on his Islington doorstep before holding an uncharacteristically subdued press conference on Friday morning, it didn’t really look that way.

One group of Tory remainers watching the speech on TV jeered out loud when a rather pale Johnson said leaving Europe needn’t mean pulling up the drawbridge; that this epic victory for Nigel Farage could somehow “take the wind out of the sails” of anyone playing politics with immigration. Too late for all that now, one said.

he scariest possibility, however, is that he actually meant it. That like most of Westminster, Johnson always imagined we’d grudgingly vote to stay in the end. That he too missed the anger bubbling beneath the surface, and is now as shocked as anyone else by what has happened.

“People talk about reluctant remainers, but I think there have been a lot of reluctant Brexiters around, people who voted leave thinking it wouldn’t happen but they’d be able to vent and to tell all their friends at dinner parties they’d done it,” said one Tory minister.

“He thought what all those reluctant Brexiters thought: it would be a vote for remain, he would be seen as having stood up for a principle.” After which leave’s newest martyr could simply have bided his time for a year or so before being triumphantly installed in Downing Street.

It’s perfectly possible, of course, that the Tories on both sides who suspect Johnson was never an outer in his bones are plain wrong, that the anonymous Labour MP who hotly accused him on Friday of jeopardising thousands of ordinary people’s jobs just to secure one for himself was doing him a terrible injustice.

Perhaps Johnson really did have a last-minute epiphany, declaring for leave in the sober realisation that this was always how it might end – Scotland demanding independence, Northern Ireland’s fragile political settlement at risk, Marine Le Pen jubilant, the Bank of England stumping up £250bn to stabilise the market. Perhaps he’s still convinced all will be fine eventually.

And let’s hope to God he’s right. Any remainer who doesn’t pray to be proved wrong about Brexit is callous, wishing disaster on people who are unable to afford it. But right now, what scorched earth Johnson stands to inherit – a nation febrile and divided, teetering on the brink of economic and constitutional crisis. It’s all over for David Cameron now. But it feels, too, like the end of a broader modernising movement to which both he and Johnson belonged.

Johnson is far from a buffoon. He’s an agile thinker, gifted communicator and natural opportunist who made a reasonable fist of governing London after recruiting some reliable deputies (enter Michael Gove). He’s smart enough to have learned from the recent Labour leadership campaign – in which managerially competent candidates were slaughtered for being on the wrong side of a visceral grassroots argument – that elites only survive in this febrile climate by pleasing the masses. Perhaps somehow it will all come together.

It’s just that on Friday morning Johnson didn’t look like a man with a plan that’s all working perfectly. He looked more like a king unable to take more such victories.

Note EU-Digest: Following Brexit the EU must make sure not to sign any agreement with Britain which gives them preferential treatment.on Trade,Visa,Tax excemptions and immediately treat their Government and Citizens exactly as they would any other non EU country. 

In doing so it will also send a clear message not only to Britain but also to other EU nations that if you are a member of the EU you can't have your cake and eat it also.

Read more: A pyrrhic victory? Boris Johnson wakes up to the costs of Brexit | Politics | The Guardian


Britain: Latest EU referendum poll of polls: Brexit just one point behind Remain on final day of campaigning

Leaders of the Leave and Remain sides have been crossing the country all day in a frenetic final push for the winning line.

YouGov's latest EU referendum poll of polls has Leave on 44 per cent, Remain on 45 per cent and Don't Know on 11 per cent, suggesting last-minute campaigning could yet be crucial.

The bookmakers disagree, however, with most of the major gambling outlets offering odds of 3/1 on Brexit and 1/4 on Remain.

Read more: Latest EU referendum poll of polls: Brexit just one point behind Remain on final day of campaigning « Express